Capitulo 1 – Download as PDF File .pdf), Text File .txt) or read online. Introducao-Bioestatística – Uploaded by. by Deborah Rumsey and if you can read in portuguese: Introdução a Bioestatística para simples mortais, by Ulysses Doria Filho) and take my. . -assassinos-e-poetas-que-sonharam-a-independencia-do-brasil-pedro-doria .

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The ART trial and how introdui recruitment died. Moving on… The eligible patients were divided in three groups: Meaning, if you wanna treat them, do it with the right dose!

Even if the patients in the VCT group were more sick, it dorix the only group which received adequate dose treatment. Because he had to survive our attempts to kill him as intensivists until day 5. Is the HCAP concept a lie? Fikho that honest to compare this group with others? Here we have a problem, Immortal Time Bias.

There it is, nebulized and intravenous are the same? Another thing is to realize that the study compares different sites of infection and different bacterias.

Combination therapy for non-believers, and believers too!

One interesting fact is that even with lot of difference among polymyxin doses no difference in nephropathy RIFLE was showed. Nothing but the whole truth. Now, to study Klebsiella pneumoniae carbapenemase Gen2 causing blood stream infection and compare between monotherapy vs combined therapy?

For me the idea of using lower doses to avoid adverse affects might increase bacterial resistance. The median of adequate treatment for monotherapy group was ZERO! The antibiotic dose was included in the multivariate model. Interestingly, was considered polymyxin use any of: Take another look at the antibiotics doses table. Recently I did a review of literature about combination therapy for multi-drug resistant bacterias and soon you will see here.


Keep this in mind!

If you do agree, read the literature we have available today about combination therapy. I agree that is not easy to study the same bacteria, for example, Klebsiella pneumoniae carbapenemase Gen2.

Combination therapy for non-believers, and believers too! – ICU Revisited

I can show you that a patient who drinks beer at 5th day of ICU have lower mortality than a patient who does not. The only group which received polymyxin at adequate dose was the VCT group. Go hit the books then.

So, if I begin with polimyxin and just after 3 days add amikacin, this guy bioestatlstica recive amikacin is the same that our 5th day drunk guy. This was a unicentric, retrospective study that from evaluated antibiotic combinations to guide therapy in patients with extensively drug-resistant gram negative bacilli XDR GNB infections of any site.

S Army — Delta associates — Memegenerator. Why I hate tramadol but sometimes use it. Data and results Patients in the validated fklho combination therapy had more severe infections and more serious disease, monotherapy group was older.

But after a multivariate analysis the authors throw the results saying the risk of infection related mortality is 8x greater in MT group and 6x greater in NVCT group when compared to VCT group. The primary outcome was infection related mortality, which was determined by the attending physician another bias here. Both groups with combined therapy had more infections caused by Klebsiella pneumoniae and Pseudomonas aeruginosas when the monotherapy group more Acinetobacter baumannii bioestatustica.


Therefore, if you read an article showing a ulusses association between combined therapy and lower mortality and take this as true I can recommend you two books Statistics for Dummies, by Deborah Rumsey and if you can read in portuguese: This is gonna be a revolving theme here, so keep your eyes open!

All these information makes me wonder about the results of the multivariate analysis. Patients were included if: Iboestatistica, beer drinkers have lower mortality than sober patients.

To begin with, I can do an observational trial, either retrospective or prospective, showing that doctors who drink wine 7 days a week have more sex.

Combination therapy for non-believers, and believers too!

Escritos de Fernando Macedo e Thais Barros: Palavras 2

Patients in the validated polymyxin combination therapy had more severe infections and more serious disease, monotherapy group was older. From a statistical point of view, the drinker only begin to exist at day In their majority, the most cited, bioestatisticz observational trials.

And also other strange things happened.