The objective of the present study was to design and formulate TDDS of topiramate (TPM) and to evaluate their extended release in vitro and ex. used were of analytical grade. Preparation of TDDS. Composition of formulation of transdermal patches was showed in Table 1. The polymeric solution (10%. The purpose of this research work was to Formulation and evaluation of transdermal drug systems (TDDS) which can deliver medicines via the skin portal to.

Author: Daimuro Meztijar
Country: Syria
Language: English (Spanish)
Genre: Marketing
Published (Last): 23 September 2012
Pages: 229
PDF File Size: 15.70 Mb
ePub File Size: 12.77 Mb
ISBN: 376-6-34878-626-6
Downloads: 51570
Price: Free* [*Free Regsitration Required]
Uploader: Tamuro

Accuracy The accuracy was determined by recovery studies. The structure of acrylate monomers.

From these values, it was observed that the thickness of the polymer depends on the solubility and concentration of the polymer. This article forumlation been cited by other articles in PMC. Data acquisition and processing were dealt with by Waters Empower professional software. The experiments were conducted in triplicate. The transdermal patches of TPM prepared evaaluation solvent casting method using a combination of ethylcellulose, PVP, eudragit LCAP, carbopol in various ratios using PG as plasticizers and oleic acid, Tween 80 as a permeation enhancers were studied.

Formulation and evaluation of transdermal drug delivery of topiramate

The formulations prepared with Eudragit L was found to have the highest value of folding endurance and formulations made of CAP, PVP and carbopol respectively were found to have the lowest value of folding endurance. Frandol r tape was purchased from Yamanuchi Pharm JP 40 mg in 40 cm 2. It can be attributed to today’s advanced patch-making technology, through which nearly a billion patches are manufactured every year Prausnitz, Langer, The results of model testing are shown in Table 6.


Hairless rat skin was used to evaluate the effects of penetration enhancers on the permeation and to evaluate the permeation of ISDN release from the optimised developed patch. Repaglinide was received as a gift sample from Torrent Pharmaceutical Ltd.

The prepared ahd with different polymer concentrations were smooth, opaque, flexible and uniform.

The effects of chemical penetration enhancers, reservoir materials and rate-controlling membranes on the release behaviour of ISDN from the transdermal patch were studied, and the in vitro release of ISDN from the developed patch was studied and compared with the commercially available ISDN patch.

Relationship between the pharmacodynamics and pharmacokinetics of two oral sustained-release formulations of isosorbide dinitrate in normal man. It belongs to class 2 drug. Drug-loaded matrix-type transdermal patches of Repaglinide were prepared by using solvent casting method. Drug release studies The release characteristics of all prepared formulations were studied in vitro and compared.

Formulation and evaluation of transdermal drug delivery of topiramate

The drug reservoir layer was separated carefully from the glass plate, and then pressed tightly on the rate-controlling membrane. All the prepared formulations were subjected for preliminary screening to check the effect of various polymer combinations. The patches were nad subjected to various physical evaluations along with the ex vivo permeation studies using pig ear skin. The number of times the film was folded at the same place without breaking gave the value of the folding endurance.

International Scholarly Research Notices

Schmook et al compared the penetration properties of tdda skin with animal pig and rat skin for four topical formulxtion drugs salicylic acid, hydrocortisone, clotrimazole and terbinafine with widely varying polarity.


Three different patches from three batches, each with an area of 1 cm 2were weighed individually, and the average weight and standard deviation was calculated.

Thus, we could surmise the permeation rates of the drug transporting through the human skin would be less than the values of rat skin.

To further illustrate how the penetration enhancers affected the permeation rates, the release behaviours of ISDN in the formulation groups F2, F3, F4 and F5 transporting across the rats’ ex-vivo skin were studied. Last, the polyester film laminate 3M, Scotchpak TMas a backing layer, covered the reservoir. How to cite this article.

Formulation and evaluation of transdermal drug-delivery system of isosorbide dinitrate

Formulation of transdermal an In the present study, drug loaded matrix type transdermal patches of TPM were prepared by solvent casting method[ 21 ] using different ratios of hydroxyl propyl methyl cellulose HPMCethyl cellulose, polyvinylpyrrolidone PVPeudragit L, Cellulose acetate phthalate CAPcarbopol and polyvinyl alcohol PVA.

However, above-mentioned parameters were also studied for optimized formulations with permeation enhancers, but no significant change was found in these parameters with permeation rormulation.

Formulation and evaluation of transdermal patch of Aceclofenac. This work was supported by the national significant and special project of new created drugs No. The developed patch was fabricated by a temporary liner, an adhesive layer, a rate-controlling membrane, a reservoir and a backing. Soud A, Panchagnub R. The lf compartment of the diffusion cell was filled with phosphate buffer pH 7.