Disease definition. Fetal hydantoin syndrome is a drug-related embryofetopathy that can occur when an embryo/fetus is exposed to the anticonvulsant drug. A clinical diagnosis of fetal hydantoin syndrome secondary to in utero phenytoin exposure was considered. Investigations showed vitamin D. This page includes the following topics and synonyms: Fetal Hydantoin Syndrome.
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Definition NCI A teratogenic disorder observed in a newborn or child of a mother who was exposed to phenytoin during pregnancy. Treatment for epilepsy in pregnancy: An increased number of fingerprint arches have also been noted. Infants with fetal hydantoin syndrome can benefit from early developmental intervention to ensure that affected children reach their potential. Fetal hydantoin syndrome is a hydantoln pattern of mental and physical birth defects that results from maternal use of the anti-seizure anticonvulsant drug phenytoin Dilantin during pregnancy.
Limping walk Click here to view. Affected infants often develop similar symptoms regardless of the associated drug, particularly symptoms affecting the head and face region craniofacial abnormalities. Differential Diagnosis Fetal Alcohol Syndrome.
Rare Disease Database
Investigational Therapies Information on current clinical trials is posted on the Internet at www. As affected children grow older, the developmental delays improve, but studies suggest that children may remain slightly behind unexposed siblings.
Band and loop space maintainer 85 region Click here to view. Phenytoin is often given with other anti-seizure drugs and other adjunct medications that may influence development of the disorder.
Fetal Hydantoin Syndrome
Am J Med Genet A. Oguni M, Osawa M. Affected Populations Fetal hydantoin syndrome affects males and females in equal numbers. Prevalence and pattern of epilepsy in India. Some infants may have increased hair on the body and face. The epidemiology of epilepsy in Rochester, Minnesota, through Congenital malformation due to exogenous toxicity Syndromes. How to cite this article: Views Read Edit View history. These images are a random sampling from a Bing search on the term “Fetal Hydantoin Syndrome.
You can help by adding to it. The range and severity of associated abnormalities will vary greatly from one infant to another.
Congenital malformation due to exogenous toxicity Q86 Infants with fetal valproate syndrome are at a greater risk of developing neurological abnormalities than are infants whose mothers took other types of anti-seizure medications. Search Bing for all related images. Int J Dev Neurosci.
How to cite this URL: NORD has a separate report called fetal valproate syndrome that discusses infants whose mothers took valproate during pregnancy.
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Fetal Hydantoin Syndrome – NORD (National Organization for Rare Disorders)
Psychosocial support for the entire family is essential as well. Some current clinical trials also are posted on the following page on the NORD website: Buehler BA, Finnell R. NORD has a separate report on fetal valproate syndrome. Search other sites for ‘Fetal Hydantoin Syndrome’. Fetal alcohol spectrum disorder. NeonatalAntenatal ICD Prenatal prediction of risk of the fetal hydantoin syndrome.
The content of the website and databases of the National Organization for Rare Disorders NORD is copyrighted and may not be reproduced, copied, downloaded or disseminated, in any way, for any commercial or public purpose, without prior written authorization and approval from NORD. Another theory speculates that intermediate metabolites of phenytoin are responsible for its fetaal.
Treatment The treatment of fetal hydantoin syndrome is directed toward the specific symptoms that are apparent in each individual.
In addition, the potential role of other factors remains unclear, such as genetic influences that affect phenytoin metabolism or additional environmental factors e. Fetal hydantoin syndrome may be caused by a combination of specific genetic and environmental factors. Syndromes of the Hydantokn and Neck.
Fetal dihydantoin syndrome Phenytoin embryofetopathy Prevalence: Fetal antiepileptic drug exposure: Only comments written in English can be processed. Borderline to mild intellectual disability has been reported in some cases, and some studies have suggested that children exposed to phenytoin fetsl the womb have a greater risk of developing learning disabilities, particularly hdyantoin verbal skills.
Symptoms may not be noticeable at birth congenitalbut will become apparent as an affected child grows older. N Engl J Med. Researchers believe the disease can be transmitted genetically as an autosomal dominant trait but most cases appear to be the result of a new mutation. Therefore, it is important to note that affected individuals may not have all of the symptoms discussed below.
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