DEFISIENSI ENZIM G6PD PDF

Patofisiologi Defisiensi Enzim G6PD. NADPH yang dihasilkan dalam lintasan pentose fosfat oleh aktifitas G6PD berperan dalam eritrosit untuk mereduksi. Defisiensi Enzim Glukosa 6 Fosfat Dehidrogenase (G6PD) – Download as Powerpoint Presentation .ppt /.pptx), PDF File .pdf), Text File .txt) or view. PERBANDINGAN KADAR BILIRUBIN NEONATUS DENGAN DAN TANPA DEFISIENSI GLUCOSEPHOSPHATE DEHYDROGENASE, INFEKSI DAN TIDAK.

Author: Kelkis Kagak
Country: Hungary
Language: English (Spanish)
Genre: Finance
Published (Last): 10 November 2014
Pages: 480
PDF File Size: 5.94 Mb
ePub File Size: 18.75 Mb
ISBN: 573-7-27834-401-9
Downloads: 78514
Price: Free* [*Free Regsitration Required]
Uploader: Bramuro

To function properly, the cells need an enzyme called glucose-6 phosphate dehydrogenase G6PD.

What is G6PD Deficiency: Symptoms, Causes, Diagnosis, and Treatment

Every organ in the body needs a steady supply of oxygen-rich blood to function properly. G6PD often reacts to certain triggers.

The K acetylated G6PD is incapable of dfeisiensi active dimers and displays a complete loss of activity. The disorder is more predominant in males and patients are usually asymptomatic. Clinically, an X-linked genetic deficiency of G6PD predisposes a person to non-immune hemolytic anemia. EC number Enzyme superfamily Enzyme family List of enzymes.

Robbins and Cotran Pathologic Basis of Disease. Glucosephosphate dehydrogenase 6-phosphogluconolactonase Phosphogluconate dehydrogenase. There are about nine variants of G6PD deficiency. Hydrogen bonding and electrostatic interaction network green. G6PD deficiency cannot be cured, but it is very possible to minimize the symptoms. Key Symptoms The symptoms of G6PD, such as jaundice, weakness, fatigue, heavy breathing, and a weak pulse, are common with other diseases.

Many variants of G6PD, mostly produced from missense mutationshave been described with wide-ranging levels of enzyme activity and associated clinical symptoms.

When a patient is diagnosed dfeisiensi G6PD deficiency, the doctor will analyze what triggered the condition. If the kidney has been affected, dialysis may be performed. G6PD is negatively regulated by acetylation on lysine Lysan evolutionarily conserved residue. Biochemical and Biophysical Research Communications. Not to be confused with Glucose 6-phosphatase. G6PD is remarkable for its genetic diversity.

  KEVIN MITNICK GHOST IN THE WIRE PDF

By using this site, you agree to the Terms of Use and Privacy Defisidnsi. Guaranteed Best Price The concern of medical tourists is that a private physician or clinic may charge them more than a local emzim. Since G6PD is an inherited disorder, one of the common ensim of people diagnosed with the condition is the chances of them passing on the disorder to their children. The body is usually able to produce a sufficient amount of red blood cells to replace those that die naturally, but with cells dying sooner than expected, the body is unable to keep up with the demand.

The red blood cells are responsible for delivering the nutrients and oxygen that the organs need. Comptes Rendus Biologies in French.

Thus, regulation of G6PD has downstream consequences for the activity of the rest of the pentose phosphate pathway. Yeast G6PD is inhibited by long chain fatty acids according to two older publications [13] [14] and might be product inhibition in fatty acid synthesis which requires NADPH. This page was last edited on 28 Julyat Regulation can also occur through genetic pathways.

Glucosephosphate dehydrogenase – Wikipedia

With access to crystal structures, some scientists have tried to model the structures of other mutants. As one of the largest medical tourism companies in the region, we are able to secure and share the critical information that is most linked to quality and cost of care.

Treatment methods currently available are designed to control the symptoms rather than correct the condition. If the condition is severe, which means that the red blood cells are being destroyed at an alarming rate acute hemolysisthe doctor may recommend a blood transfusion. G6PD is widely distributed in many species from bacteria to humans.

  FANUC A06B-6058 PDF

In particular, there is a strong network of hydrogen bonding with electrostatic charges being diffused across multiple atoms through hydrogen bonding with 4 water molecules see figure. Asia’s Largest Physician Network DocDoc has Asia’s largest healthcare physician network with 23, doctors, clinics and 55 hospitals from various specialties throughout the region.

The structural site has been shown to be important for maintaining the long term stability of the enzyme. Thus, mutations in these critical areas are possible without completely disrupting the function of G6PD. Glucose oxidase L-gulonolactone oxidase Xanthine oxidase. Retrieved 13 December In fact, knowing defksiensi the triggers involves certain types of food, medications, and infections, among others are and avoiding them help patients avoid the symptoms altogether.

Hydrophobic stacking interactions green. Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator. Cell growth and proliferation are affected by G6PD.

Malate dehydrogenase quinone Quinoprotein glucose dehydrogenase. Glucosephosphate dehydrogenase is stimulated by its substrate G6P. Slightly different view than the first panel.

DocDoc has Asia’s largest healthcare physician network with 23, doctors, clinics and 55 hospitals from various specialties throughout the region. Other species experience a variation in G6PD as well.