Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Abstract. AVILA, Rodolfo Esteban et al. Mucoepidermoid Carcinoma of Salivary Glands: Histological and Inmunohistochemical Prognostic Factors. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el.

Author: Kigagore Maukree
Country: Morocco
Language: English (Spanish)
Genre: Medical
Published (Last): 14 June 2013
Pages: 104
PDF File Size: 17.84 Mb
ePub File Size: 3.30 Mb
ISBN: 892-9-26755-364-5
Downloads: 46054
Price: Free* [*Free Regsitration Required]
Uploader: Brasida

MECs were staged according to the TNM classification of malignant tumors, 12 and minor salivary gland tumors were staged according to their site of origin in a similar fashion to squamous cell carcinomas.

Carcinoma mucoepidermoide

Coexpression of p53 and c-erbB-2 proteins is associated with histological type, tumour stage, and cell carcjnoma in malignant salivary gland tumours. Mucoepidegmoide Head Neck Surg. Sinonasal and maxillary tumors were not included in the sample. Mucoepidermoid carcinoma of the head and neck: Thus, our findings may suggest the lack of association among clinicopathological features and the immunoexpression of c-erbB Concerning MEC, there had been only individual case descriptions of c-erbB-2 expression Kernohan et al.

Future investigations could benefit from this study, helping to provide further strategies for more efficient management of MECs.

Mucoepidermoid carcinoma MEC is the most common epithelial neoplasm in the salivary mucoepidsrmoide the biological behavior relates to a histological grade of the tumor low, intermediate and high grade.

Mucoepidermoid carcinoma of intraoral salivary glands. However, many studies found that benign and malignant salivary gland neoplasms with evidence of myoepithelial lineage do not overexpress c-erbB-2 glanduals which support the view that this growth receptor is not involved in their pathogenesis Rosa et al.

The disease-free interval for recurrences and metastases ranged from 22 to months and 22 to months, respectively. Histological classification of salivary gland tumours.

Histological features and prognosis of patients with mucoepidermoid carcinoma of the parotid gland. Muc4 and erbb2 expression in major and minor salivary gland mucoepidermoid carcinoma. Different conclusions may be attributed to the varying techniques used, criteria applied to determine positive c-erbB-2 expression, the diversity of lesions and the limited number evaluated in some studies.


Mucoepidermoid carcinoma of the salivary glands in Brazil: The tumoral histological grade was glanduas with the ki67 expression, relevant prognosis factors in MEC.

mucoepidsrmoide Besides, in the present study a standardized method was employed for evaluation of positivity. HER2 expression in salivary gland carcinomas: Ann Otol Rhinol Laryngol.

Due to the singularity and diverse histology of these tumors, prognostic factors have been difficult to elucidate. The high percentage of previously observed positive cases 21 cases, The ki67 expression was important in high grade tumors. Blocking of endogenous avidin-botin activity in immunohistochemistry.

Although this current investigation was limited by a relatively small sample size, there was a long follow-up period in which we could verify and confirm the influence of some prognostic factors.

Discrepancies were solved by consensus. Mucoepidermoid carcinoma of minor salivary glands: Thus, the aim of this study was to analyze a series of intraoral MEC for mucoepiderjoide of the c-erbB-2 oncoprotein and its possible association with the clinicopathologic features of the sample. There have been suggestions that the overexpression of c-erbB-2 on salivary gland tumors is related with histogenesis of these lesions Glisson et al.

There were no statistically significant differences for any analyzed variable affecting OS curves.

Even though low-grade tumors did not develop metastases and high-grade tumors showed lower DFS rates after five years, no significant difference was found for the grading system or any of the evaluated prognostic factors. P; Quattrone, P; Cantu, G.

Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica

The palate was the most commonly affected site, with 21 cases Mucoepidermoid carcinoma of the salivary glands -clinical review of 42 cases. Review of the literature and clinicopathological analysis of 18 patients. Histopathologic grading of salivary gland neoplasms. Despite the small sample studied our results demonstrated no association among c-erbB-2 expression and demographic or histological grades of MEC. Sinonasal and maxillary tumors were not included in this study as intraoral salivary gland tumors since that in these locations mucoepidermoid carcinoma presents different origin rather than glandular Ellis et al.


The parotid was the most affected gland, followed by the palate and sub maxillary, which agree with the bibliography. Tumors were stratified into three groups: MEC is the most common malignancy of salivary glands and presents a diverse age distribution Auclair et al; Lopes et al.

The Kaplan-Meier method was used to plot survival curves with the log rank test for analysis of cumulative survival rates. Mucoepidermoid carcinoma of the salivary glands clinical review of 42 cases. We undertook this study to analyze the histological grade and proliferative potential as prognostic factors, important to guide the treatment and design recommendations, in a series of 13 patients who were treated for MEC of principal and accessory salivary glands between and From oral biopsies submitted during period between and ,40 0.

There were 16 cases of MEC diagnosed over an year period at our institution, which is similar to results reported by Triantafillidou and others 14 who found 16 cases over a year interval. Salivary gland neoplasms, mucoepidermoid carcinoma, disease-free survival.

Briefly, 4 um sections were dewaxed in xylene and hydrated with graded ethanol.

Carcinoma mucoepidermoide

In contrast carcinoa results reported by Nance and others 4 in present study was not observed any glandlas between positive surgical margins and decreased DFS. The DFS was calculated as the time interval between the date of first treatment and the date of local disease recurrence or last information for censored observations when the patient was known to be disease-free.

However, other studies reported a rare expression of c-erbB-2 on these tumors Kernohan et al.

The biological features and clinical behavior of mucoepidermoid carcinomas are widely variable and poorly understood.