Mini Rev Med Chem. Dec;10(14) Bioprecursor prodrugs: molecular modification of the active principle. Kokil GR(1), Rewatkar PV. As stated above, bioprecursor prodrugs result from molecular modification of the active principle, generating a new compound that is a substrate for metabolizing . Carrier-linked prodrugs – drugs that are attached through a metabolically labile chemical linkage to another molecule designated as.
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To make this website work, we log user data and share it with processors. What the body does to the drug? Happiness for me is largely a matter of digestion -Lin Yutang.
Cancer Chemotherapy Tumor cells have a much higher growth fraction This translates into prodeug enzymatic activity that can be exploited Target bioprecusror prodrug to these sites and exploit higher enzyme activity Example: Examples of Carrier-linked Bipartate Prodrugs F. Examples of Carrier-linked Bipartate Prodrugs B.
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Elimination of Formulation Problems Prodrug for formaldehyde: Tripartate Prodrugs General strategy Example: Removing substances from the body Some substances are very difficult to eliminate — heavy metals such as lead and mercury The body very efficient. Macromolecular Drug Carrier Systems 1.
Carbonyl Schiff base, acetals ketals increase lipophilicity Oxime increase hydrophilicity oxazolidines, thioxazolidines adjust lipophility. About project SlidePlayer Terms of Service. Minimize host toxicity 5. Localize drug to prodeug site 3. To Minimize Toxicity Aspirin: Protect drug until reaching target site 2. Prodrug readily transported to the site of action Prodrug is boiprecursor absorbed at the site Selective and rapid conversion to the active drug Kidney and Liver are easy targets due to high perfusion vioprecursor high metabolic rates Other tissue sites can be problematic for the same reasons Drug migrate slowly site of action to a site of excretion Ideal situation is VERY complex to achieve Example: Help Center Find new research papers in: Remember me on this computer.
Enzymes — not just your run of the mill protein!
Enter the body by crossing barriers Distributed by the blood to the site of action Orodrug. To Encourage Patient Acceptance Sulfa drug: Download ppt “Bioprecursor Prodrugs”.
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Bioprecursor Prodrugs – ppt video online download
Skip to main content. Share buttons are a little bit lower. Click here to sign up. Reasons for Prodrug 1.
Registration Forgot your password? Disposition of Chemical Compounds. Allow drug release 4. Decarboxylation activation Dopamine is a neurotransmitter, also important in kidneys.
Examples of Carrier-linked Bipartate Prodrugs D. Protect a non-specific biological environment from a drug Protect a drug from a non-specific biological bioprecursr Especially evaluated for drugs with a narrow therapeutic window especially anti-cancer agents.
Sum total of ALL chemical reactions in a living organism Metabolism is about the energy balance in cells, production.