Annona muricata has been attributed with numerous health benefits – including anticancer properties. The aim of this study was to carry out anticancer. Annona muricata L. (A. muricata) is a species of the Annonaceae family that has been . The increasingly popular use of A. muricata as an anticancer treatment. Extensive anticancer investigations have been conducted on A. muricata due to its reported ethnomedicinal uses against.

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Oxidative Medicine and Cellular Longevity

Anticancer effects of AGEs and extracts derived from the different aerial organs of A. Assessment of elemental content muricqta the fruit of graviola plant, Annona muricatafrom some selected communities in ghana by instrumental neutron activation analysis.

Hazards and risks in oncology: This promising investigation continued on mouse xenograft model and the results showed remarkable 56, 54, and However, it is advisable to avoid excessive and long term consumption of products containing A. The authors declare that the research annpna conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Its fruits are edible, heart-shaped, green in color and 15—20 cm in diameter. Therefore, the strong antitumor activity exerted by the extracts might be associated with the presence of cytotoxic constituents in the extracts particularly annonacin.

Cytotoxicity was not noted at the concentrations tested in this study [ 67 ]. Afr J Biomed Res. Annonacin, annonacin A, annonacin B, annonacinone, muricatalicin and muricatalin have been isolated and identified by Yu et al.

According to the available data, there are about seven AGEs and five extracts which annoan demonstrated antiproliferative activity. Their results indicated that a the ethanolic extract was superior to the aqueous extract with respect to both reducing power and in vitro antioxidant activity and b the ethanolic extract, but not the aqueous extract, was selectively cytotoxic to three tumor cell lines as opposed to no effect on normal spleen cells [ 93 ].


These authors reported that a graviola was superior to J. Although the development of intensity modulated radiotherapy IMRT to replace conventional radiation therapy allows the parotid glands to be spared 7 and results in an overall increase in the quality of life of patients 8exposure to high doses of IMRT radiation reportedly causes dysphagia in patients 9.

Functional outcomes and rehabilitation strategies in patients treated with chemoradiotherapy for advanced head muricatta neck cancer: The seeds are used as an anti-anthelmintic against external and internal worms and parasites. Besides the anti-inflammatory and anticancer properties, the leaves of A. The inability of cells to execute apoptosis to remove cancer cells was observed in multiple cancer types, including breast, pancreatic, ovarian and colorectal cancers 61 — J Alt Complement Med.

Berberine, a natural product, induces G1-phase cell cycle arrest and caspasedependent apoptosis in human prostate carcinoma cells.

Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review

Two new mono-tetrahydrofuran ring acetogenins, annomuricin E and muricapentocin, from the leaves of Annona muricata. Sufficient preclinical data and safety data generated will allow clinical trials to be pursued on this plant and its bioactive compounds.

Antimalarial and murkcata activities of ethnopharmacologically selected medicinal plants from South Vietnam. Extracts derived from seeds are toxic to annoan Hep G2 [ 31 ] cancer cells, while extracts from leaf, pericarp, seed, and stem have each shown cytotoxicity towards hematological malignant cells such as the leukemia U cell line [ 5669 ]. In addition to benefits in terms of improving the health of users, the ingredients used in CAM that are usually extracted from resources such as plants and animals are assumed to be safe for consumption.


However, more rigorous evaluation of various plant parts, their extracts, and ultimately isolated bioactive compounds is clearly warranted. Antiulcerogenic activity of the hydroalcoholic extract of leaves of Annona muricata Linnaeus in mice. The methanolic extract was found to confer superior protection against hydrogen peroxide-induced DNA damage [ ].


Kamaraj C, Rahuman AA. The capability of inducing cancer anticaancer cytotoxicity has been one of the main reasons behind the increased interest among scientists in the benefits of CAM, especially plant-based CAMs.

Complementary and alternative medicine is defined as means of treatment that are outside the scope of modern medicinal treatment. A dysfunctional apoptotic pathway is one of the main contributors to carcinogenesis. From all these findings, not only the leaves, the whole A. In addition to examining antioxidant activity of this extract see discussion abovethese authors also performed histological and immunohistochemical analysis of wounds treated with ointments containing the extract using intrasite gel as a positive control.

Notwithstanding, if there is unabating inflammation or if the system fails anona return to normal homeostasis it eventually leads to chronic inflammation which is identified as a root cause in the development of a variety of chronic inflammatory and immune-related diseases Arshad et al. Thorough investigations have been carried out on the leaves of A. Ethnopharmacognostic observations on Panamanian medicinal plants.